我们通过一项全国性队列研究，调查韩国痛风患者的癌症风险。

数据来自韩国国家医疗保险服务数据库。痛风患者的定义是2008年至2010年期间确诊为痛风并接受抗痛风药物治疗(别嘌呤醇、秋水仙碱和苯溴马隆)的≥ 20岁患者。频率匹配年龄和性别后，将指甲疾病患者随机分配到对照组(1:1)。然后调查2012年至2018年期间的癌症发病率。在对伴随疾病进行调整后，Cox比例风险回归分析用于研究痛风与癌症之间的关联。

本研究包括179，930名痛风患者和同等数量的匹配对照。痛风患者的总体癌症发病率高于对照组(发病率比，1.08)。Cox比例风险回归分析显示，在对伴随疾病进行调整后，痛风的相关风险比为1.053 (95%置信区间，1.031至1.077)。痛风与癌症的高风险相关，尤其是食道癌、胃癌、结肠癌、肝癌、胰腺癌、肺癌、卵巢癌、肾癌和膀胱癌。

Abstract

Background/aims: Using a nationwide cohort, we investigated the cancer risk in Korean patients with gout.

Methods: Data were obtained from the Korean National Health Insurance Service Database. Patients with gout were defined as those aged ≥ 20 years who were diagnosed with gout and received anti-gout medication (allopurinol, colchicine, and benzbromarone) between 2008 and 2010. Patients with nail disorders were randomly assigned to a control group (1:1 ratio) after frequency matching for age and sex. Cancer incidence was then investigated between 2012 and 2018. Cox proportional hazard regression analysis was used to investigate the association between gout and cancer after adjusting for concomitant diseases.

Results: This study included 179,930 patients with gout and an equal number of matched controls. The incidence of overall cancer was higher in patients with gout than in controls (incidence rate ratio, 1.08). Cox proportional hazards regression analysis showed that gout was associated with a hazard ratio of 1.053 (95% confidence interval ,1.031 to 1.077) after adjusting for concomitant diseases.

Conclusion: Gout was associated with a significantly high risk of cancer, especially esophageal, stomach, colon, liver, pancreatic, lung, ovarian, renal, and bladder cancers.

原文链接

pubmed.ncbi.nlm.nih.gov/32872748/

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