医微客 - 【直播预告】 2023CSCO指南会精彩来袭！

【直播预告】 2023CSCO指南会精彩来袭！

热点资讯

2023-04-23

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为积极推动我国临床肿瘤学事业的发展、提高临床肿瘤医师的临床与科研水平，进一步促进CSCO诊疗指南的制定和推广，由中国临床肿瘤学会和北京市希思科临床肿瘤学研究基金会联合主办的2023年CSCO指南会将于4月21-22日在广州召开。

会议设有胃癌、食管癌、黑色素瘤、肺癌、乳腺癌、胆道恶性肿瘤、头颈部肿瘤、血液肿瘤、免疫指南等18大专场会，由国内各肿瘤领域知名家齐聚一堂，以讲座和报告的形式对 2023 年度 CSCO 指南更新的亮点、要点、难点进行了深入讲解和研讨。

直播日程：4月21日-22日全天直播

https://uploader.shimo.im/f/HRZpn20hkGeVnzcD.png!thumbnail"},"29:0|30:0|3:\"1862\"|4:\"auto\"|crop:\"\"|frame:\"none\"|ori-height:\"412\"|ori-width:\"1862\"],[20,"\n","24:\"2Njs\"|direction:\"ltr\"],[20,"http://dx.doi.org/10.1136/bmjmed-2022-000335";],[20,"\n","24:\"f5pH\"|7:1|direction:\"ltr\"],[20,"\n","24:\"XsAx\"|direction:\"ltr\"],[20,"咖啡因（Caffeine）是一种甲基黄嘌呤类中枢神经系统兴奋剂，是世界上消费最广泛的精神活性物质，生活中主要来源于咖啡、茶、苏打饮料等。"],[20,"\n","24:\"ljMB\"|direction:\"ltr\"],[20,"\n","24:\"XST7\"|direction:\"ltr\"],[20,"事实上，“咖啡因能够减肥并降低与肥胖相关的疾病风险”并不是个新观点。咖啡因具有产热作用，先前的短期对照试验也证实，较高的咖啡因摄入量能有效降低体重、体重指数（BMI）以及体脂率。"],[20,"\n","24:\"4ocQ\"|direction:\"ltr\"],[20,"\n","24:\"9tx4\"|direction:\"ltr\"],[20,"而在此基础上，咖啡因的摄入量自然也能降低与肥胖相关的疾病风险。一项涵盖了30个前瞻性研究的、超118千万名参与者的大型Meta分析显示，每天每多饮用一杯咖啡（平均含70–150mg咖啡因），患2型糖尿病的风险会随之降低7%。"],[20,"\n","24:\"zu1v\"|direction:\"ltr\"],[20,"\n","24:\"MmxS\"|direction:\"ltr\"],[20,"但迄今为止发表的大多数研究都是观察性的，无法排除其他潜在的影响因素，因而不能确定咖啡因与疾病之间的因果关系。为了克服这些问题，研究者搭建了孟德尔随机化框架，利用咖啡因代谢的遗传变异，探究血浆中咖啡因含量高与肥胖、2型糖尿病和主要心血管疾病之间的因果影响。"],[20,"\n","24:\"4RMh\"|direction:\"ltr\"],[20,"\n","24:\"DZIF\"|direction:\"ltr\"],[20,{"gallery":"https://uploader.shimo.im/f/uD9x8q5TQ4uYMKdp.png!thumbnail"},"29:0|30:0|3:\"2590\"|4:\"auto\"|crop:\"\"|frame:\"none\"|ori-height:\"828\"|ori-width:\"2590\"],[20,"\n","24:\"Z5p7\"|direction:\"ltr\"],[20,"研究设计图"],[20,"\n","24:\"4n0e\"|7:1|direction:\"ltr\"],[20,"\n","24:\"hFLH\"|direction:\"ltr\"],[20,"在孟德尔随机化研究中，找到与咖啡因代谢速度相关的基因是非常关键的一步——本研究中确定的位点为CYP1A2（与咖啡因在肝脏中的代谢相关）和AHR（调节CYP1A2的表达）基因。拥有这两种基因变异的参与者，体内咖啡因的代谢速度更慢，血浆中的咖啡因含量也会更高，依此来评估咖啡因对疾病的影响。"],[20,"\n","24:\"seT7\"|direction:\"ltr\"],[20,"\n","24:\"GPIi\"|direction:\"ltr\"],[20,"结果显示，遗传预测的血浆中咖啡因浓度越高，意味着BMI和全身脂肪质量越低，但与去脂体重无关。"],[20,"\n","24:\"2m0n\"|direction:\"ltr\"],[20,"\n","24:\"U3OD\"|direction:\"ltr\"],[20,"在不同的人群中，遗传预测的血浆中咖啡因每增加1个标准差，发生2型糖尿病的风险会降低19-23%。换言之，血浆中咖啡因含量越高，发生2型糖尿病的风险也越低。"],[20,"\n","24:\"zwxk\"|direction:\"ltr\"],[20,"\n","24:\"xODn\"|direction:\"ltr\"],[20,{"gallery":"https://uploader.shimo.im/f/HbONpXS1gpWCC7XL.png!thumbnail"},"29:0|30:0|3:\"1850\"|4:\"auto\"|crop:\"\"|frame:\"none\"|ori-height:\"1526\"|ori-width:\"1850\"],[20,"\n","24:\"qwqh\"|direction:\"ltr\"],[20,"基因预测的血浆咖啡因浓度越高，2型糖尿病以及心血管疾病的发生风险"],[20,"\n","24:\"xELR\"|7:1|direction:\"ltr\"],[20,"\n","24:\"dReF\"|direction:\"ltr\"],[20,"进一步的因果分析显示，血浆中咖啡因含量对2型糖尿病发生风险的影响，很大程度上是由BMI的降低驱动的。数据显示，咖啡因降低2型糖尿病风险的作用，有43%可以归因于减肥。"],[20,"\n","24:\"6nic\"|direction:\"ltr\"],[20,"\n","24:\"bZ2F\"|direction:\"ltr\"],[20,"简单来说，血浆中咖啡因含量的增加，使得BMI和全身脂肪质量降低，自然也会降低2型糖尿病的发生风险。"],[20,"\n","24:\"n9l8\"|direction:\"ltr\"],[20,"\n","24:\"Z2T8\"|direction:\"ltr\"],[20,{"gallery":"https://uploader.shimo.im/f/vX0Jpgfhg5fDOP6S.png!thumbnail"},"29:0|30:0|3:\"2584\"|4:\"auto\"|crop:\"\"|frame:\"none\"|ori-height:\"838\"|ori-width:\"2584\"],[20,"\n","24:\"exes\"|direction:\"ltr\"],[20,"因果定向图"],[20,"\n","24:\"zSln\"|7:1|direction:\"ltr\"],[20,"\n","24:\"XMAd\"|direction:\"ltr\"],[20,"看来，喝咖啡减肥还真不是说说而已，研究者也解释了背后的生物机制——咖啡因能通过增加产热和脂肪氧化来降低BMI和脂肪质量；因此，血浆咖啡因的含量越高，产热反应的效果也越好，消耗的能量自然更高。"],[20,"\n","24:\"lmqO\"|direction:\"ltr\"],[20,"\n","24:\"5raC\"|direction:\"ltr\"],[20,"数据显示，每天摄入约100mg咖啡因，能使消耗的能量增加约100kcal（418.4kJ），从而降低肥胖症的发生风险。而市面上售卖的咖啡中，一份浓缩约含60-75mg的咖啡因。想要减肥的朋友们，还不赶紧喝起来，简直就是“坐躺瘦”！"],[20,"\n","24:\"1mRg\"|direction:\"ltr\"],[20,"\n","24:\"gScX\"|direction:\"ltr\"],[20,"咖啡和茶爱好者狂喜，让咖啡因在我的血管中狂奔吧！"],[20,"\n","24:\"Jurl\"|direction:\"ltr\"],[20,"\n","24:\"w3cX\"|direction:\"ltr\"],[20,{"gallery":"https://uploader.shimo.im/f/xZyDLEx25lYlynLb.png!thumbnail"},"29:0|30:0|3:\"333px\"|4:\"326px\"|crop:\"\"|frame:\"none\"|ori-height:\"812\"|ori-width:\"828\"],[20,"\n","24:\"kqAg\"|7:1|direction:\"ltr\"],[20,"图源：网络"],[20,"\n","24:\"sF85\"|7:1|direction:\"ltr\"],[20,"\n","24:\"3w6c\"|direction:\"ltr\"],[20,"\n","24:\"mFJ8\"|direction:\"ltr\"],[20,"参考资料："],[20,"\n","24:\"LQoY\"|direction:\"ltr\"],[20,"[1] Larsson SC, Woolf B, Gill DAppraisal of the causal effect of plasma caffeine on adiposity, type 2 diabetes, and cardiovascular disease: two sample mendelian randomisation studyBMJ Medicine 2023;2:doi: 10.1136/bmjmed-2022-000335"],[20,"\n","24:\"CIyI\"|direction:\"ltr\"],[20,"[2]"],[20,"https://medicalxpress.com/news/2023-03-high-blood-caffeine-curb-amount.html";,"16:\"https%3A%2F%2Fmedicalxpress.com%2Fnews%2F2023-03-high-blood-caffeine-curb-amount.html\"],[20,"\n","24:\"Cmxn\"|direction:\"ltr\"],[20,"[3] Carlström M, Larsson SC. Coffee consumption and reduced risk of developing type 2 diabetes: a systematic review with meta-analysis. Nutr Rev. 2018 Jun 1;76(6):395-417. doi: 10.1093/nutrit/nuy014. PMID: 29590460."]]" data-copy-origin="https://shimo.im">