Zhang YX,  Breast Cancer Res Treat. 2022 Apr 18. 

探究乳腺癌患者体重变化与预后的相关性结果的关系。 目前研究对绝经状态和内分泌治疗与其关联的影响仍然知之甚少

研究纳入2016名乳腺癌患者并进行随访，多变量Cox模型用于评估体重变化与无进展生存期(PFS)的关系

研究表明体重减轻不利于乳腺癌预后，尤其是对绝经后妇女而言，而体重增加是接受内分泌治疗患者的潜在有益指标，但对非内分泌治疗患者则不然

Abstract

Purpose: Results of the associations between weight change after breast cancer diagnosis and prognosis were inconsistent. The modification effects of menopausal status and endocrine therapy on the associations remain poorly understood.

Methods: A total of 2016 breast cancer patients were recruited between October 2008 and January 2018 and followed up until December 31, 2019 in Guangzhou. Multivariate Cox models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) for progression-free survival (PFS) in association with weight change after diagnosis.

Results: Weight loss at 2 years (HR = 1.34, 95% CI 0.87-2.06) or more than 2 years (HR = 1.95, 95% CI 1.22-3.10) after diagnosis increased risk of breast cancer progression. The adverse effect of weight loss was significantly more pronounced in post-menopausal than pre-menopausal women, particularly for weight loss at 2 years after diagnosis, with the HRs and 95% CIs of 2.41 (1.25-4.63) and 0.90 (0.49-1.64), respectively. Weight gain tended to reduce the risk of disease progression among patients with endocrine therapy but not for those with non-endocrine therapy; the significant interaction between weight gain at 2 years after diagnosis and endocrine therapy was observed (Pinteraction = 0.042).

Conclusion: Our finding suggested that weight loss was detrimental to breast cancer prognosis, particularly for post-menopausal women, while weight gain may be a potential beneficial indicator for the patients with endocrine therapy but not for those with non-endocrine therapy.

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