Anna M. Kucharska-Newton，1* Keri L. Monda，1 Suzette J. Bielinski，2 Eric Boerwinkle，3 Thomas D. Rea，4 Wayne D. Rosamond，1 James S. Pankow，5 Anna K?ttgen，6 Gerardo Heiss，1 and Kari E. North1

    1Department of Epidemiology， Gillings School of Global Public Health， University of North Carolina at Chapel Hill， Chapel Hill， NC 27514， USA
    2Division of Epidemiology， Department of Health Services Research， Mayo Clinic， Rochester， MN 55905， USA
    3Human Genetics Center and Division of Epidemiology， University of Texas， Houston， TX 77225， USA
    4Department of Medicine， University of Washington， Seattle， WA 98195， USA
    5Division of Epidemiology and Community Health， University of Minnesota， Minneapolis， MN 55454， USA
    6Department of Epidemiology， Johns Hopkins University， Baltimore， MD 21205， USA
    *Anna M. Kucharska-Newton: Email: anna_newton@unc.edu
    Academic Editor: Gianluca Iacobellis
    Received June 29， 2009; Revised December 10， 2009; Accepted January 14， 2010.
    This is an open access article distributed under the Creative Commons Attribution License， which permits unrestricted use， distribution， and reproduction in any medium， provided the original work is properly cited.
Abstract
    We examined the association of variation in the type 2 diabetes risk-conferring TCF7L2 gene with the risk of incident coronary heart disease (CHD) among the lean， overweight， and obese members of the Atherosclerosis Risk in Communities (ARIC) Study cohort. Cox proportional hazard regression analyses were performed using a general model， with the major homozygote as the reference category. For 9，865 whites， a significant increase in the risk of CHD was seen only among lean ( BMI < 25kg/m2) individuals homozygous for the T allele of the TCF7L2 rs7903146 gene risk variant (hazard ratio 1.42; 95% CI 1.03，1.97; P = .01). No association was found among 3，631 blacks， regardless of BMI status. An attenuated hazard ratio was observed among the nondiabetic ARIC cohort members. This study suggests that body mass modifies the association of the TCF7L2 rs7903146 T allele with CHD risk.
 

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